Yingning Zhang

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

Mark R. Hutchinson, Yingning Zhang, Mitesh Shridhar et al. · Brain Behavior and Immunity · 2009 · 562 citations

Opioid Epidemic, Molecular Pharmacology, Health Sciences +12

Non‐stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll‐like receptor 4 (TLR4)

Mark R. Hutchinson, Yingning Zhang, Kimberley Brown et al. · European Journal of Neuroscience · 2008 · 389 citations · Full text

Pain Therapy, Pain Disorders, Pain Medicine +22

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

Peter M. Grace, Keith A. Strand, Erika L. Galer et al. · Proceedings of the National Academy of Sciences · 2016 · 370 citations · Full text

Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia

Mark R. Hutchinson, Benjamen D. Coats, Susannah S. Lewis et al. · Brain Behavior and Immunity · 2008 · 300 citations · Full text

Inflammation, Anti-inflammatory, Chronic Analgesia +10

Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia

Mark R. Hutchinson, Alexis L. Northcutt, Lindsey W. Chao et al. · Brain Behavior and Immunity · 2008 · 175 citations · Full text

Psychiatry, Pain Medicine, Medicine +10