Food & Function · 2022 · 58 citations · 43 references
Life SciencesMicrobiologyNutritionInflammationMicrobial MetabolismNutritional BiochemistryGut HealthGut MicrobiomeGut MicrobiotaLactic Acid BacteriaMetabolic InflammationMicrobiome DysbiosisGut Microbiome DysbiosisGut Microbiota CompositionGut Microbiota DysbiosisGut Microbiota EffectsHepatic Insulin ResistanceIntestinal Barrier IntegrityNonalcoholic Fatty Liver Disease-associated Insulin ResistanceNonalcoholic Fatty Liver Disease-related Dyslipidemia
further proved that the effects of DQW on the attenuation of hepatic insulin resistance were mediated by the PPARα and IRS1/PI3K/AKT pathways. Taken together, these results indicated that DQW treatment could attenuate HFD-induced NAFLD and insulin resistance by modulating gut microbiota composition, enhancing the SCFA levels, and activating the PPARα and IRS1/PI3K/Akt pathways.
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An obesity-associated gut microbiome with increased capacity for energy harvest
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Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice
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Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
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