Discovery of a 2,6-diarylpyridine-based hydroxamic acid derivative as novel histone deacetylase 8 and tubulin dual inhibitor for the treatment of neuroblastoma

Polypharmacology by Design: A Medicinal Chemist’s Perspective on Multitargeting Compounds

Ewgenij Proschak, Holger Stark, Daniel Merk · Journal of Medicinal Chemistry · 2018 · 476 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Histone Deacetylase 8 in Neuroblastoma Tumorigenesis

Ina Oehme, Hedwig E. Deubzer, Dennis Wegener et al. · Clinical Cancer Research · 2008 · 401 citations · Full text

Medicine, Cancer Biology, Oncology +14

Class III β-tubulin expression and in vitro resistance to microtubule targeting agents

Chloé Stengel, Stephen T. Newman, Mathew P. Leese et al. · British Journal of Cancer · 2009 · 191 citations · Full text

Medicine, Oncology, Pharmacology +16

Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth

María‐Jesús Pérez‐Pérez, Eva‐María Priego, Oskía Bueno et al. · Journal of Medicinal Chemistry · 2016 · 181 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation

I Rettig, E Koeneke, Franziska Trippel et al. · Cell Death and Disease · 2015 · 180 citations · Full text

Medicine, Cancer Biology, Pharmacology +12