Concepedia

Dimethyl Itaconate Reduces Cognitive Impairment and Neuroinflammation in APPswe/PS1ΔE9 Transgenic Mouse Model of Alzheimer’s Disease

Jing Xiong, Donglin Lu, Bai-Qiang Chen, Tongyun Liu, Zixuan Wang

NeuroMolecular Medicine · 2022 · 24 citations · 19 references

DOI

Concepts

References

19

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

Maj-Linda B. Selenica, Milene L. Brownlow, Jeffy P. Jimenez et al. · Neurodegenerative Diseases · 2012 · 10.4K citations · Full text

, , +17

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag et al. · Nature · 2018 · 1.8K citations

, , +12

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

Eri Kobayashi, Takafumi Suzuki, Ryo Funayama et al. · Nature Communications · 2016 · 1.8K citations · Full text

, , +17

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

Alessandro Michelucci, Thekla Cordes, Jenny Ghelfi et al. · Proceedings of the National Academy of Sciences · 2013 · 1.2K citations · Full text

, , +16

Itaconic Acid Is a Mammalian Metabolite Induced during Macrophage Activation

Cheryl L. Strelko, Wenyun Lu, Fay J. Dufort et al. · Journal of the American Chemical Society · 2011 · 385 citations

, , +17