Concepedia

USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent autophagy

Qianqian Di, Xibao Zhao, Haimei Tang, Xunwei Li, Yue Xiao, Han Wu, Zherui Wu, Jiazheng Quan, Weilin Chen

Autophagy · 2022 · 73 citations · 22 references

DOIFull text

Open access

Concepts

Abstract

ATG5: autophagy related 5; ATP: adenosine triphosphate; CASP1: caspase 1; IL18: interleukin 18; IL1B/IL-1β: interleukin 1 beta; LPS: lipopolysaccharide; NLRC4: NLR family, CARD domain containing 4; NLRP3: NLR family, pyrin domain containing 3; PYCARD/ASC: PYD and CARD domain containing; TNF/TNF-α: tumor necrosis factor; USP22: ubiquitin specific peptidase 22.

References

22

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, , +15