Exogenous ketone ester administration attenuates systemic inflammation and reduces organ damage in a lipopolysaccharide model of sepsis

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Public Health, Infectious Diseases, Epidemiologic Methods +14

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

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Veterinary Medicine, Emergency Medicine, Infectious Diseases +16

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

Yun‐Hee Youm, Kim Nguyen, Ryan W. Grant et al. · Nature Medicine · 2015 · 2.1K citations · Full text

Life Sciences, Immunology, Pharmacology +14

Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

Tadahiro Shimazu, Matthew D. Hirschey, Wenjuan He et al. · Science · 2012 · 1.7K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

Ikuo Kimura, Daisuke Inoue, Takeshi Maeda et al. · Proceedings of the National Academy of Sciences · 2011 · 1.1K citations · Full text

Life Sciences, Endocrinology, Physiology +12