Empagliflozin Blunts Worsening Cardiac Dysfunction Associated With Reduced NLRP3 (Nucleotide-Binding Domain-Like Receptor Protein 3) Inflammasome Activation in Heart Failure

Nikole J. Byrne, Nobutoshi Matsumura, Zaid H. Maayah, +15

Circulation Heart Failure

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells

Mourad Ferdaoussi, Xiao-Qing Dai, Mette V. Jensen, +27

Journal of Clinical Investigation

Metabolic RemodelingCellular PhysiologyInsulin SignalingMetabolic SyndromeSignaling Pathway +18

G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1

Mourad Ferdaoussi, Valérie Bergeron, Bader Zarrouki, +8

Diabetologia

Molecular PhysiologySignal TransductionBiochemistryG Protein-coupled ReceptorMedicine +7

Human high-density lipoprotein particles prevent activation of the JNK pathway induced by human oxidised low-density lipoprotein particles in pancreatic beta cells

Amar Abderrahmani, Guy Niederhäuser, D. Favre, +6

Diabetologia

Insulin SignalingHuman High-density LipoproteinMolecular PhysiologySignal TransductionBiochemistry +10

Exendin-4 Protects β-Cells From Interleukin-1β–Induced Apoptosis by Interfering With the c-Jun NH2-Terminal Kinase Pathway

Mourad Ferdaoussi, Saida Abdelli, Jiang-Yan Yang, +8

Diabetes

Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NF-κB Signalling

Julie Amyot, Meriem Semache, Mourad Ferdaoussi, +2

PLoS ONE

Chronically Elevating Circulating Ketones Can Reduce Cardiac Inflammation and Blunt the Development of Heart Failure

Nikole J. Byrne, Shubham Soni, Shingo Takahara, +13

Circulation Heart Failure

Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism

Jessica Gooding, Mette V. Jensen, Xiao-Qing Dai, +6

Cell Reports

Metabolomics ProfilingInsulin SignalingMetabolic SyndromePituitary GlandInsulin Secretagogue Derived +18

Interleukin-1 signaling contributes to acute islet compensation

Catherine Hajmrle, Nancy Smith, Aliya F Spigelman, +5

JCI Insight

ImmunologyInsulin SignalingInflammationObesityMetabolic Syndrome +17

Empagliflozin suppresses inflammation and protects against acute septic renal injury

Zaid H. Maayah, Mourad Ferdaoussi, Shingo Takahara, +2

Inflammopharmacology

InflammationAnti-inflammatoryMedicineImmunologyRenal Inflammation +7