Concepedia

Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition

Carina Glas, Eli Naydenova, Severin Lechner, Nathalie Wössner, Liu Yang, Johannes C. B. Dietschreit, Hongyan Sun, Manfred Jung, Bernhard Küster, Christian Ochsenfeld,

European Journal of Medicinal Chemistry · 2022 · 14 citations · 34 references

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34

Mass-spectrometry-based draft of the human proteome

Mathias Wilhelm, Judith Schlegl, Hannes Hahne et al. · Nature · 2014 · 1.9K citations

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Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

Jintang Du, Yeyun Zhou, Xiaoyang Su et al. · Science · 2011 · 1.4K citations · Full text

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SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

Jeong-Soon Park, Yue Chen, Daniel X. Tishkoff et al. · Molecular Cell · 2013 · 1K citations · Full text

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Relative Binding Free Energy Calculations in Drug Discovery: Recent Advances and Practical Considerations

Zoe Cournia, Bryce K. Allen, Woody Sherman · Journal of Chemical Information and Modeling · 2017 · 839 citations · Full text

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SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

Takashi Nakagawa, David J. Lomb, Marcia C. Haigis et al. · Cell · 2009 · 779 citations · Full text

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