Concepedia

Escape from cell-cell and cell-matrix adhesion dependence underscores disease progression in gastric cancer organoid models

Yin Tong, Priscilla S.W. Cheng, Chung Sze Or, Sarah S K Yue, Hoi Cheong Siu, Siu Lun Ho, Simon Law, Wai Yin Tsui, Dessy Chan, Stephanie Ma,

Gut · 2022 · 22 citations · 32 references

DOI

Abstract

The CCi/CMi phenotype has a critical role in malignant transformation and tumour progression, offering new mechanistic information on RHO-ROCK pathway inhibition that contributes to GC pathogenicity.

References

32

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Comprehensive molecular characterization of gastric adenocarcinoma

Adam J. Bass, Scott Frazer · Nature · 2014 · 6.3K citations · Full text

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

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Disruption of epithelial cell-matrix interactions induces apoptosis

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