Biomaterials Science · 2022 · 27 citations · 27 references
MedicineOncologyPharmacologyDrug DeliveryRadiation SafetyRadiobiologyNanomedicineNanoparticle DesignNanotoxicologyRadiation BiologyRadiation TherapyRadiation ToxicityBioactivityNanoparticlesRadiation DamageRadiation Effects On The Gastrointestinal TractRadioprotective AgentsRadioprotective EffectsRadioprotective MaterialsRadioprotective Mechanisms
intestinal stem cells (ISCs) and promoted cell regeneration after IR, which indicated that the regeneration ability of ISCs was maintained and the repair of intestinal structure and function was promoted. Finally, PDA-NPs significantly suppressed the apoptosis, inflammatory pyroptosis and DNA damage of intestinal cells induced by ionizing radiation. Altogether, our study suggested that PDA-NPs may have great potential in protecting the intestines from ionizing radiation damage.
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Identification of stem cells in small intestine and colon by marker gene Lgr5
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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
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The role of radiotherapy in cancer treatment
Geoff P. Delaney, Susannah Jacob, C. Featherstone et al. · Cancer · 2005 · 1.7K citations · Full text