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Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 1

Medicinal ChemistryPart 1Pharmaceutical ScienceMedicinePathologyPharmacological AgentPharmacotherapyAnti-cancer AgentDrug DevelopmentPharmacologyPharmaceutical ChemistryTumor BiologyDrug Discovery