Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

Abstract

(Cell Reports 33, 108493-1–19.e1–e16; December 15, 2020) In the originally published version of this paper, the CHMP4B sgRNA sequence listed in the STAR Methods section was incorrect. The incorrect sequence was 5′-TCGATGGCACAAGCCATGAA, which is an sgRNA designed to target CHMP2A. The correct CHMP4B-targeting sgRNA sequence that was used in the experiments for this paper is 5′- TATCAACCATCGAGTTCCAG. This change does not affect the data or conclusions of the study and now appears in the paper online. The authors apologize for any inconvenience this error may have caused. Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16qNeggers et al.Cell ReportsDecember 15, 2020In BriefNeggers et al. identify the ATPases VPS4A and VPS4B as selective vulnerabilities and potential therapeutic targets in cancers harboring loss of chromosome 18q or 16q. In VPS4B-deficient cancers, VPS4A suppression leads to ESCRT-III dysfunction, nuclear deformation, and abscission defects. Moreover, ESCRT proteins and interferons can modulate dependency on VPS4A. Full-Text PDF Open Access