Jasper E. Neggers

XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer

Jimi Kim, Elizabeth A. McMillan, Hyun Seok Kim et al. · Nature · 2016 · 207 citations · Full text

Tumor Biology, Xpo1-dependent Nuclear Export, Oncology +10

Identifying Drug-Target Selectivity of Small-Molecule CRM1/XPO1 Inhibitors by CRISPR/Cas9 Genome Editing

Jasper E. Neggers, Thomas Vercruysse, Maarten Jacquemyn et al. · Chemistry & Biology · 2015 · 131 citations

Natural Sciences, Molecular Biology, Gene Editing +10

Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes

Jasper E. Neggers, Bert Kwanten, Tim Dierckx et al. · Nature Communications · 2018 · 105 citations · Full text

Drug Target, Engineering, Genetics +16

Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer

Douglas E. Biancur, Kevin S. Kapner, Keisuke Yamamoto et al. · Cell Metabolism · 2020 · 78 citations · Full text

Pancreatic Cancer, Medicine, Cancer Genomics +4

The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia

Thomas Vercruysse, Jolien De Bie, Jasper E. Neggers et al. · Clinical Cancer Research · 2016 · 66 citations · Full text