Meloxican: Influence on arachidonic acid metabolism

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Life Sciences, Medicinal Chemistry, Pharmacology +10

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

Jane A. Mitchell, Pravit Akarasereenont, Christoph Thiemermann et al. · Proceedings of the National Academy of Sciences · 1993 · 1.7K citations

Medicine, Pharmacology, Inflammation +9

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

Elizabeth A. Meade, William L. Smith, David L. DeWitt · Journal of Biological Chemistry · 1993 · 1.3K citations · Full text

Medicine, Biochemistry, Pharmacology +15

Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids

Kanato Yamagata, Katrin I. Andreasson, Walter E. Kaufmann et al. · Neuron · 1993 · 1.2K citations

Life Sciences, Neurobiology, Neuroscience +14