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Publication | Open Access

Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway

DOIFull Paper Access

460

Citations

56

References

2022

Year

Ruozhi Dang, Mingyang Wang, Xinhui Li, Haiyang Wang, Lanxiang Liu, Qingyuan Wu, Jianting Zhao, Ping Ji, Lianmei Zhong, Julio Licínio,
Journal of Neuroinflammation

Abstract

These findings suggest that EDA possesses potent antidepressant and anxiolytic properties through Sirt1/Nrf2/HO-1/Gpx4 axis and Gpx4-mediated ferroptosis may play a key role in this effect.

References

YearCitations

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