Concepedia

Treg tissue stability depends on lymphotoxin beta-receptor- and adenosine-receptor-driven lymphatic endothelial cell responses

Vikas Saxena, Wenji Piao, Lushen Li, Christina Paluskievicz, Yanbao Xiong, Thomas Simon, Ram Lakhan, C. Colin Brinkman, Sarah L. Walden, Keli L. Hippen,

Cell Reports · 2022 · 30 citations · 52 references

DOIFull text

Open access

Concepts

Abstract

and resist exTreg conversion in an adenosine-receptor-2A-dependent fashion. Human Tregs migrating across human LECs behave similarly. These molecular interactions can be targeted for therapeutic manipulation of immunity and suppression.

References

52

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Jason D. Fontenot, Marc A. Gavin, Alexander Y. Rudensky · Nature Immunology · 2003 · 7.7K citations

, , +14

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

Jason D. Fontenot, Jeffrey P. Rasmussen, Luke M. Williams et al. · Immunity · 2005 · 2.2K citations · Full text

, , +14

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

Xuyu Zhou, Samantha L. Bailey-Bucktrout, Lukas T. Jeker et al. · Nature Immunology · 2009 · 1.3K citations · Full text

, , +14

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

Noriko Komatsu, Kazuo Okamoto, Shinichiro Sawa et al. · Nature Medicine · 2013 · 1.1K citations

, , +17

Foxp3-dependent programme of regulatory T-cell differentiation

Marc A. Gavin, Jeffrey P. Rasmussen, Jason D. Fontenot et al. · Nature · 2007 · 1.1K citations · Full text

, , +14