Concepedia

Blockade of integrin signaling reduces chemotherapy-induced premature senescence in collagen cultured bladder cancer cells

Linghui Deng, Kun Jin, Xianghong Zhou, Zilong Zhang, Liming Ge, Xingyu Xiong, Xingyang Su, Di Jin, Qiming Yuan, Chichen Zhang,

Precision Clinical Medicine · 2022 · 10 citations · 16 references

DOIFull text

Open access

Abstract

Based on our finding that integrin β1/AKT acted primarily to impart premature senescence to bladder cancer cells cultured in collagen gel, we suggest that integrin β1 might be a feasible target for bladder cancer eradication.

References

16

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram et al. · CA A Cancer Journal for Clinicians · 2018 · 86.6K citations · Full text

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

Joon-Il Jun, Lester F. Lau · Nature Cell Biology · 2010 · 942 citations · Full text

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p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer

James G. Jackson, Vinod Pant, Qin Li et al. · Cancer Cell · 2012 · 327 citations · Full text

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Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation

David A. Gewirtz, Shawn E. Holt, Lynne W. Elmore · Biochemical Pharmacology · 2008 · 275 citations

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Drug-induced Senescence Generates Chemoresistant Stemlike Cells with Low Reactive Oxygen Species

Santhi Achuthan, T.R. Santhoshkumar, J. V. Prabhakar et al. · Journal of Biological Chemistry · 2011 · 203 citations · Full text