Blockade of integrin signaling reduces chemotherapy-induced premature senescence in collagen cultured bladder cancer cells - Concepedia

Concepedia

Publication | Open Access

Blockade of integrin signaling reduces chemotherapy-induced premature senescence in collagen cultured bladder cancer cells

DOI Full Paper Access

10

Citations

16

References

2022

Year

Linghui Deng, Kun Jin, Xianghong Zhou, Zilong Zhang, Liming Ge, Xingyu Xiong, Xingyang Su, Di Jin, Qiming Yuan, Chichen Zhang,

Precision Clinical Medicine

Abstract

Based on our finding that integrin β1/AKT acted primarily to impart premature senescence to bladder cancer cells cultured in collagen gel, we suggest that integrin β1 might be a feasible target for bladder cancer eradication.

References

	Year	Citations
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, CA A Cancer Journal for Clinicians	2018	86.6K
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing Joon-Il Jun, Lester F. Lau Nature Cell Biology InflammationFibroblast SenescenceFibrosisMatricellular Protein Ccn1Cutaneous Biology	2010	942
p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer James G. Jackson, Vinod Pant, Qin Li, Cancer Cell Breast OncologyLongevityMedicineApoptosisApoptotic Response	2012	327
Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation David A. Gewirtz, Shawn E. Holt, Lynne W. Elmore Biochemical Pharmacology Lifespan ExtensionMedicineCellular SenescenceTumor Cell ResponseRadiation Oncology	2008	275
Drug-induced Senescence Generates Chemoresistant Stemlike Cells with Low Reactive Oxygen Species Santhi Achuthan, T.R. Santhoshkumar, J. V. Prabhakar, Journal of Biological Chemistry	2011	203
Cilengitide: An RGD Pentapeptide ανβ3 and ανβ5 Integrin Inhibitor in Development for Glioblastoma and Other Malignancies David A. Reardon, Bart Neyns, Michael Weller, Future Oncology ImmunotherapeuticsHigh-grade GliomasGliomaTumor BiologyNeuro-oncology	2011	105
Loss of <scp>MT</scp> 1‐ <scp>MMP</scp> causes cell senescence and nuclear defects which can be reversed by retinoic acid Ana Gutiérrez‐Fernández, Clara Soria‐Valles, Fernando G. Osorio, The EMBO Journal Genome InstabilityDevelopmental BiologyCell RegulationNatural SciencesRetinoic Acid	2015	93
β1-Integrin binding to collagen type 1 transmits breast cancer cells into chemoresistance by activating ABC efflux transporters Fabian Baltes, Vladlena Pfeifer, Katja Silbermann, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Type 1β1-Integrin BindingCell AdhesionMedicineCancer Cell Biology	2020	79
Antisense Bcl-xl down-regulation switches the response to topoisomerase I inhibition from senescence to apoptosis in colorectal cancer cells, enhancing global cytotoxicity. Richard L. Hayward, Janet S. Macpherson, Jeff Cummings, PubMed	2003	68
Integrin α6β4-Src-AKT signaling induces cellular senescence by counteracting apoptosis in irradiated tumor cells and tissues Seung Hee Jung, Minyoung Lee, Hyun A. Park, Cell Death and Differentiation Tumor BiologySignal TransductionIrradiated Tumor CellsMedicineApoptosis	2018	48

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