Concepedia

Integrin Inhibitors

Integrin Inhibitor is a class of biologic therapeutic agents that selectively block integrin-mediated leukocyte trafficking to intestinal mucosa, thereby reducing inflammatory activity in ulcerative colitis.

562

Publications

42K

Citations

4.3K

Authors

1.1K

Institutions

Publications per year

2017–2026

145

Parents

Publications

562

Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease

William J. Sandborn, Brian G. Feagan, Paul Rutgeerts et al. · New England Journal of Medicine · 2013 · 2.7K citations · Full text

, , +14

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

Gabriele Weitz‐Schmidt, Karl Welzenbach, Volker Brinkmann et al. · Nature Medicine · 2001 · 1K citations

, , +14

Natalizumab Induction and Maintenance Therapy for Crohn's Disease

William J. Sandborn, Jean‐Frédéric Colombel, Roberts Enns et al. · New England Journal of Medicine · 2005 · 926 citations · Full text

, , +17

<i>N</i>-Methylated Cyclic RGD Peptides as Highly Active and Selective α<sub>V</sub>β<sub>3</sub>Integrin Antagonists

Michael A. Dechantsreiter, Eckart Planker, Barbara Mathä et al. · Journal of Medicinal Chemistry · 1999 · 827 citations · Full text

, , +17

Effects of Vedolizumab Induction Therapy for Patients With Crohn’s Disease in Whom Tumor Necrosis Factor Antagonist Treatment Failed

Bruce E. Sands, Brian G. Feagan, Paul Rutgeerts et al. · Gastroenterology · 2014 · 705 citations · Full text

, , +15

1–5 of 562

Authors

4.3K

  1. WJ
    William J. Sandborn

    University of California San Diego, United States

    20 publications · 6.3K citations

    17

    h-index

  2. SV
    Séverine Vermeire

    KU Leuven, Belgium

    17 publications · 2.2K citations

    15

    h-index

  3. BG
    Brian G. Feagan

    Western University, Canada

    17 publications · 6.8K citations

    15

    h-index

  4. SD
    Silvio Danese

    Humanitas University, Italy

    12 publications · 1.3K citations

    11

    h-index

  5. BE
    Bruce E. Sands

    Icahn School of Medicine at Mount Sinai, United States

    12 publications · 4.5K citations

    11

    h-index

1–5 of 4.3K

Institutions

1.1K

  1. University of California San Diego

    San Diego, United States

    21 h-index

    54 publications

    7.1K citations

  2. Merck KGaA, Darmstadt (Germany)

    Darmstadt, Germany

    16 h-index

    52 publications

    10.3K citations

  3. Harvard University

    Cambridge, United States

    16 h-index

    54 publications

    8.5K citations

  4. Western University

    London, Canada

    16 h-index

    30 publications

    7.9K citations

  5. KU Leuven

    Leuven, Belgium

    14 h-index

    46 publications

    7.2K citations

  6. Technical University of Munich

    Munich, Germany

    13 h-index

    56 publications

    10.2K citations

  7. Takeda (United States)

    Deerfield, United States

    13 h-index

    55 publications

    8.5K citations

  8. University of Chicago

    Chicago, United States

    13 h-index

    19 publications

    5.7K citations

1–8 of 1.1K

Venues

  1. Journal of Biological Chemistry

    JBC · 23 publications · 2.4K citations

    22

    h-index

  2. PubMed

    Repository · 25 publications · 1.9K citations

    17

    h-index

  3. Inflammatory Bowel Diseases

    19 publications · 1K citations

    15

    h-index

  4. Bioorganic & Medicinal Chemistry Letters

    22 publications · 502 citations

    14

    h-index

  5. Journal of Medicinal Chemistry

    15 publications · 1.9K citations

    14

    h-index

1–5