Efficient polymer nanoparticle-mediated delivery of gene editing reagents into human hematopoietic stem and progenitor cells

Search-and-replace genome editing without double-strand breaks or donor DNA

Andrew V. Anzalone, Peyton B. Randolph, Jessie R. Davis et al. · Nature · 2019 · 4.4K citations · Full text

Genome Surgery, Medicine, Genetics +5

CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia

Haydar Frangoul, David Altshuler, Maria Domenica Cappellini et al. · New England Journal of Medicine · 2020 · 1.7K citations · Full text

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

John A. Zuris, David B. Thompson, Yilai Shu et al. · Nature Biotechnology · 2014 · 1.4K citations · Full text

Lipid Preparation, In Vivo Gene Therapy, Biochemistry +10

Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles

Ming Wang, John A. Zuris, Fantao Meng et al. · Proceedings of the National Academy of Sciences · 2016 · 606 citations · Full text

Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing

Tuo Wei, Qiang Cheng, Yi-Li Min et al. · Nature Communications · 2020 · 560 citations · Full text