Concepedia

Adipocyte-specific Nos2 deletion improves insulin resistance and dyslipidemia through brown fat activation in diet-induced obese mice

Vanessa Rodrigues Vilela, Nolwenn Samson, Renato Tadeu Nachbar, Lia Rossi Perazza, Gabriel Lachance, Volatiana Rokatoarivelo, Carolina Centano‐Baez, Patrícia Zancan, Mauro Sola‐Penna, Kerstin Bellmann,

Molecular Metabolism · 2022 · 14 citations · 32 references

DOIFull text

Open access

Abstract

These results demonstrate the key role of adipocyte NOS2 in the development of obesity-linked insulin resistance and dyslipidemia, partly through NO-dependent inhibition of BAT mitochondrial bioenergetics.

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