Concepedia

ATRX loss promotes immunosuppressive mechanisms in IDH1 mutant glioma

Chengchen Hu, Kimberly Wang, Ceylan Damon, Yi Fu, Tengjiao Ma, Lisa E. Kratz, Bachchu Lal, Mingyao Ying, Shuli Xia, Daniel P. Cahill,

Neuro-Oncology · 2021 · 47 citations · 37 references

DOIFull text

Open access

Abstract

ATRX loss activates a BRD-dependent immune-suppressive transcriptome and immune escape mechanism in IDH1R132H/p53mut astrocytoma cells.

References

37

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

New England Journal of Medicine · 2015 · 3.2K citations · Full text

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

Muhammad Zaeem Noman, Giacomo Desantis, Bassam Janji et al. · The Journal of Experimental Medicine · 2014 · 2.1K citations · Full text

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Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

Ángel García-Díaz, Daniel Sanghoon Shin, Blanca Homet Moreno et al. · Cell Reports · 2017 · 1.8K citations · Full text

Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma

Brett Johnson, Tali Mazor, Chibo Hong et al. · Science · 2013 · 1.4K citations · Full text

Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

Andrew T. Parsa, James S. Waldron, Amith Panner et al. · Nature Medicine · 2006 · 1.3K citations

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