Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction of B cell numbers

A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus

Richard Furie, Michelle Petri, Omid Zamani et al. · Arthritis & Rheumatism · 2011 · 1.7K citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +17

Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations

Fabienne Mackay, Stephen A. Woodcock, Pornsri Lawton et al. · The Journal of Experimental Medicine · 1999 · 1.5K citations · Full text

Life Sciences, Immunology, Pathology +17

Excess BAFF Rescues Self-Reactive B Cells from Peripheral Deletion and Allows Them to Enter Forbidden Follicular and Marginal Zone Niches

Marilyn Thien, Tri Giang Phan, Sandra Gardam et al. · Immunity · 2004 · 724 citations · Full text

Life Sciences, Cell Biology, Immunology +16

Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation

Jonathan A. Deane, Prapaporn Pisitkun, Rebecca S. Barrett et al. · Immunity · 2007 · 621 citations · Full text

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Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival

Anne J. Novak, Jaime Darce, Bonnie K. Arendt et al. · Blood · 2003 · 557 citations · Full text

Medicine, Hematology, Oncology +10