Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation

CpG motifs in bacterial DNA trigger direct B-cell activation

Arthur Μ. Krieg, Ae‐Kyung Yi, Sara Matson et al. · Nature · 1995 · 3.5K citations

Natural Sciences, Virulence Factor, Cpg Motifs +4

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

Rie Watanabe‐Fukunaga, Camilynn I. Brannan, Neal G. Copeland et al. · Nature · 1992 · 2.9K citations

Lymphoproliferation Disorder, Knockout Mouse, Autoimmune Disease +12

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

Elizabeth A. Leadbetter, Ian R. Rifkin, Andreas M. Hohlbaum et al. · Nature · 2002 · 1.9K citations

Toll-like Receptors, Molecular Immunology, Chromatin +13

Recognition of single-stranded RNA viruses by Toll-like receptor 7

Jennifer M. Lund, Lena Alexopoulou, Ayuko Sato et al. · Proceedings of the National Academy of Sciences · 2004 · 1.8K citations · Full text

Toll-like Receptor 7, Toll-like Receptors, Virus Structure +14

Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7

Veit Hornung, Margit Guenthner‐Biller, Carole Bourquin et al. · Nature Medicine · 2005 · 1.2K citations · Full text

Innate Immune System, Immunology, Immune Regulation +16