Concepedia

Discovery of novel pyrazole-containing benzamides as potent RORγ inverse agonists

Tao Wang, Daliya Banerjee, Tonika Bohnert, Jianhua Chao, Istvan Enyedy, Jason D. Fontenot, Kevin R. Guertin, Howard Jones, Edward Yin-Shiang Lin, D.J. Marcotte,

Bioorganic & Medicinal Chemistry Letters · 2015 · 35 citations · 11 references

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11

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivaylo I. Ivanov, Brent S. McKenzie, Liang Zhou et al. · Cell · 2006 · 5.1K citations · Full text

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Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials

Richard G. Langley, Boni E. Elewski, Mark Lebwohl et al. · New England Journal of Medicine · 2014 · 2K citations · Full text

, , +14

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

Thomas G. Gant · Journal of Medicinal Chemistry · 2013 · 758 citations

, , +13

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

Jun R. Huh, Monica Leung, Pengxiang Huang et al. · Nature · 2011 · 536 citations

, , +7

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

Laura A. Solt, Philippe Nuhant, Yongjun Wang et al. · Nature · 2011 · 505 citations

, , +14