Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series

A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release

Zhi‐Liang Chu, Christopher J. Carroll, Jean Alfonso et al. · Endocrinology · 2008 · 380 citations

Life Sciences, Endocrinology, Physiology +17

A Role for β-Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucose-Dependent Insulin Release

Zhi‐Liang Chu, Robert M. Jones, Hongmei He et al. · Endocrinology · 2007 · 292 citations

Medicine, Endocrinology, Pharmacology +17

Discovery of the First Potent and Orally Efficacious Agonist of the Orphan G-Protein Coupled Receptor 119

Graeme Semple, Beatriz Fioravanti, Imelda Calderon et al. · Journal of Medicinal Chemistry · 2008 · 142 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Proteome-Wide Reactivity Profiling Identifies Diverse Carbamate Chemotypes Tuned for Serine Hydrolase Inhibition

Jae Won Chang, Armand B. Cognetta, Micah J. Niphakis et al. · ACS Chemical Biology · 2013 · 135 citations

Life Sciences, Biochemistry, Pharmacology +17

Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile

Graeme Semple, Juerg Lehmann, Amy Wong et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 52 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14