Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules

Yue Xu, Xiuwen Zhu, Heung Sik Hahm, +4

Proceedings of the National Academy of Sciences

Cell AdhesionAdult Stem CellSpecific Growth FactorCell ProliferationRegulatory Mechanism +15

A Short Nur77-Derived Peptide Converts Bcl-2 from a Protector to a Killer

Siva K. Kolluri, Xiuwen Zhu, Xin Zhou, +17

Cancer Cell

Peptide EngineeringPeptide LibraryImmunologyCell DeathPeptide Synthesis +3

Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak

Dayong Zhai, Frédéric Luciano, Xiuwen Zhu, +3

Journal of Biological Chemistry

ImmunologyCell DeathCytoskeletonCellular PhysiologyOxidative Stress +16

Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL

Frédéric Luciano, Dayong Zhai, Xiuwen Zhu, +4

Journal of Biological Chemistry

Protein FunctionCell RegulationMedicineBimel-induced ReleaseApoptosis +10

Regioselective Synthesis of 3-Alkylindoles Mediated by Zinc Triflate

Xiuwen Zhu, A. Ganesan

The Journal of Organic Chemistry

Cross-coupling ReactionEngineeringAlkene MetathesisEffective ReagentOrganic Chemistry +8

Key Molecular Contacts Promote Recognition of the BAFF Receptor by TNF Receptor-Associated Factor 3: Implications for Intracellular Signaling Regulation

Chao‐Zhou Ni, Gagik Oganesyan, Kate Welsh, +5

The Journal of Immunology

Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor

Daniel J. Buzard, Sun Hee Kim, Luis Lopez, +40

ACS Medicinal Chemistry Letters

ImmunologyPotent Functional AntagonistInflammationRheumatoid DisorderInflammatory Rheumatic Disease +18

LMP1 Protein from the Epstein-Barr Virus Is a Structural CD40 Decoy in B Lymphocytes for Binding to TRAF3

Shuangding Wu, Ping Xie, Kate Welsh, +7

Journal of Biological Chemistry

ImmunologyMolecular BiologyImmunologic MechanismAntigen ProcessingHuman Herpesvirus +15

Chrysin induces cell growth arrest, apoptosis, and ER stress and inhibits the activation of STAT3 through the generation of ROS in bladder cancer cells

Yi Xu, Yanyue Tong, Junjie Ying, +10

Oncology Letters

Total Synthesis of Debromoflustramine B via Biomimetic Alkylative Cyclization

Gan Hup Tan, Xiuwen Zhu, A. Ganesan

Organic Letters

Three-step Total SynthesisDerivativesEngineeringBiochemistryMedicine +10