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Regioselective Synthesis of 3-Alkylindoles Mediated by Zinc Triflate
77
Citations
5
References
2002
Year
Cross-coupling ReactionEngineeringAlkene MetathesisEffective ReagentOrganic ChemistryIndole Alkylation ProceedsChemistryHeterocycle ChemistrySynthesis MethodNatural Product SynthesisSynthetic ChemistryBiomolecular EngineeringZinc Triflate
Zinc triflate was found to be an effective reagent for the C3-alkylation of indoles by alkyl halides in the presence of Hünig's base and tetrabutylammonium iodide. This new method for indole alkylation proceeds by a S(N)1-like pathway, and is general for allylic, benzylic, and tertiary halides.
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