Concepedia

The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Thushan I. de Silva, Guihai Liu, Benjamin B. Lindsey, Danning Dong, Sharon Hsu, Dhruv R. Shah, Dannielle Wellington, Adrienn Angyal, Rebecca Brown, Matthew Parker,

iScience · 2021 · 92 citations · 25 references

DOIFull text

Open access

Concepts

Abstract

. CD8+ T cell lines unable to recognize variant epitopes have diverse T cell receptor repertoires. These data demonstrate the potential for T cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T cell as well as humoral immunity.

References

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SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

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