Cell Reports · 2021 · 108 citations · 59 references
Life SciencesInfectious DiseasesMicrobiologyHost-pathogen InteractionsMolecular VirologyVirologyViral InfectionsViral PathogenesisViral Protein ProcessingHost Protease-mediated Viral Protein CleavageMechanistic ElucidationProteolytic Cleavage Of Viral PolyproteinsRegulation Of Viral Protein ProcessingViral Protease FunctionViral Protease InhibitionViral ProteasesViral Protein Degradation
Highlights d An atlas of 101 human cell substrates of SARS-CoV-2 3CL pro and 58 candidate substrates is presented d SARS-CoV-2 3CL pro redundantly targets the hippo and antiviral xenophagy pathways d Galectin-8 binds as an intracellular sensor for CoV-2 spike protein that 3CL pro cuts d Cytosolic translocation of PTBP1 from the nucleus follows proteolytic removal of an NLS
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