Tumor hypoxia: an important regulator of tumor progression or a potential modulator of tumor immunogenicity?

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

Muhammad Zaeem Noman, Giacomo Desantis, Bassam Janji et al. · The Journal of Experimental Medicine · 2014 · 2.1K citations · Full text

Medicine, Immunology, Oncology +16

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

Cesar A. Corzo, Thomas Condamine, Lily Lu et al. · The Journal of Experimental Medicine · 2010 · 1.1K citations · Full text

Medicine, Immunology, Oncology +17

Molecular landmarks of tumor hypoxia across cancer types

Vinayak Bhandari, Christianne Hoey, Lydia Liu et al. · Nature Genetics · 2019 · 717 citations

Medicine, Cancer Biology, Oncology +16

Epithelial–Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

Yanyan Lou, Lixia Diao, Edwin R. Parra et al. · Clinical Cancer Research · 2016 · 446 citations

Medicine, Immunology, Oncology +17

Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy

Priyamvada Jayaprakash, Midan Ai, Arthur Liu et al. · Journal of Clinical Investigation · 2018 · 394 citations · Full text

Medicine, Immunology, Oncology +17