Concepedia

Androgen-deprivation induced senescence in prostate cancer cells is permissive for the development of castration-resistance but susceptible to senolytic therapy

Valerie J. Carpenter, Tareq Saleh, So Min Lee, Graeme Murray, Jason Reed, Andrew J. Souers, Anthony C. Faber, Hisashi Harada, David A. Gewirtz

Biochemical Pharmacology · 2021 · 56 citations · 64 references

DOI

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64

Cancer statistics, 2020

Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2020 · 21.4K citations · Full text

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Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Jean‐Philippe Coppé · 2008 · 4.1K citations · Full text

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Darren J. Baker, Tobias Wijshake, Tamar Tchkonia et al. · Nature · 2011 · 3.6K citations · Full text

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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Jianhui Chang, Yingying Wang, Lijian Shao et al. · Nature Medicine · 2015 · 1.8K citations

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Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

Ana Krtolica, Simona Parrinello, Stephen Lockett et al. · Proceedings of the National Academy of Sciences · 2001 · 1.7K citations · Full text

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