ATM/NEMO signaling modulates the expression of PD-L1 following docetaxel chemotherapy in prostate cancer

Abstract

Our findings have revealed that a previously unrecognized ATM-NEMO signaling which induced by DTX is capable of suppressing tumor immunity by activating the expression of PD-L1, suggesting that the ATM-NEMO-NF-κB axis can be exploited to restore the immune balance and overcome cancer resistance triggered by DTX.<b>Graphic Abstract</b>: supplementary file 1.