Concepedia

Synthesis of novel 1H-Pyrazolo[3,4-b]pyridine derivatives as DYRK 1A/1B inhibitors

Areum Park, Jieon Hwang, Joo‐Youn Lee, Eun Ji Heo, Yoon-Ju Na, Sein Kang, Kyu‐Sung Jeong, Ki Young Kim, Sang Joon Shin, Hyuk Lee

Bioorganic & Medicinal Chemistry Letters · 2021 · 16 citations · 32 references

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32

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

Peng Wang, Juan Carlos Álvarez-Pérez, Dan P. Felsenfeld et al. · Nature Medicine · 2015 · 404 citations · Full text

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Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

Nora Göckler, Guillermo Jofré, Chrisovalantis Papadopoulos et al. · FEBS Journal · 2009 · 278 citations · Full text

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DYRK1A-mediated Hyperphosphorylation of Tau

Soo‐Ryoon Ryoo, Hey Kyeong Jeong, Chinzorig Radnaabazar et al. · Journal of Biological Chemistry · 2007 · 271 citations · Full text

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Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

Yasushi Ogawa, Yosuke Nonaka, Toshiyasu Goto et al. · Nature Communications · 2010 · 270 citations · Full text

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Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

Fei Liu, Zhihou Liang, Jerzy Węgiel et al. · The FASEB Journal · 2008 · 264 citations

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