Concepedia

Identification of GSPT1 as prognostic biomarker and promoter of malignant colon cancer cell phenotypes via the GSK-3β/CyclinD1 pathway

Xuan Long, Lijun Zhao, Guoqiang Li, Ziwei Wang, Zhigang Deng

Aging · 2021 · 32 citations · 20 references

DOIFull text

Open access

Concepts

Abstract

in HCT116 colon cancer cells. Taken together, our findings suggest that the GSPT1/GSK pathway exerts tumor-promoting actions in colon cancer oncogenesis and progression. The GSPT1/GSK pathway may thus be an effective target for controlling colon cancer.

References

20

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

Xinyang Song, Ximei Sun, Sungwhan F. Oh et al. · Nature · 2019 · 986 citations · Full text

, , +12

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

Mohamed Elgendy, Marco Cirò, Amir Hosseini et al. · Cancer Cell · 2019 · 312 citations · Full text

, , +14

Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling

Jorge O. Múnera, Nambirajan Sundaram, Scott A. Rankin et al. · Cell stem cell · 2017 · 257 citations · Full text

, , +16

Risk Stratification for Covert Invasive Cancer Among Patients Referred for Colonic Endoscopic Mucosal Resection: A Large Multicenter Cohort

Nicholas G. Burgess, Luke F. Hourigan, Simon Zanati et al. · Gastroenterology · 2017 · 238 citations

, , +15

Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids

Birgitta E. Michels, Mohammed H. Mosa, Barbara Streibl et al. · Cell stem cell · 2020 · 219 citations · Full text

, , +12