Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

Henner F. Farin, Ingrid Jordens, Mohammed H. Mosa, +8

Nature

Cell LineageDevelopmental BiologyMedicineAdult Stem CellGut-organ Axis +6

3D model for <scp>CAR</scp> ‐mediated cytotoxicity using patient‐derived colorectal cancer organoids

Theresa Schnalzger, Marnix HP de Groot, Congcong Zhang, +6

The EMBO Journal

Gastrointestinal OncologyMedicinePharmacologyColorectal CancerCancer Cell Biology +5

Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer

Adele M. Nicolas, Marina Pešić, Esther Engel, +23

Cancer Cell

Il-1 InhibitionRectal Cancer PatientsOncologyMedicineImmunology +13

Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids

Birgitta E. Michels, Mohammed H. Mosa, Barbara Streibl, +10

Cell stem cell

Human Colon OrganoidsPathologyColorectal CancerGenome EngineeringGenome Editing +7

A Wnt-Induced Phenotypic Switch in Cancer-Associated Fibroblasts Inhibits EMT in Colorectal Cancer

Mohammed H. Mosa, Birgitta E. Michels, Constantin Menche, +4

Cancer Research

PathologyWnt-induced Phenotypic SwitchCancer BiologyTumor BiologySignaling Pathway +17

Human colon organoids reveal distinct physiologic and oncogenic Wnt responses

Birgitta E. Michels, Mohammed H. Mosa, Britta M. Grebbin, +8

The Journal of Experimental Medicine

InflammationTumor BiologyAdenoma Polyposis ColiMedicinePhysiology +13

Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses

Henner F. Farin, Mohammed H. Mosa, Benardina Ndreshkjana, +28

Cancer Discovery

Synthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy

Larsen Vornholz, Sophie E. Isay, Zsuzsanna Kurgyis, +11

Science Advances

ImmunologyImmunologic MechanismSting EnforcementCheckpoint Inhibitor TherapyImmune Cell Therapy +14

Dynamic Formation of Microvillus Inclusions During Enterocyte Differentiation in Munc18-2–Deficient Intestinal Organoids

Mohammed H. Mosa, Ophélie Nicolle, Sophia Maschalidi, +7

Cellular and Molecular Gastroenterology and Hepatology

Loss of SUV420H2-Dependent Chromatin Compaction Drives Right-Sided Colon Cancer Progression

Verawan Boonsanay, Mohammed H. Mosa, Mario Looso, +9

Gastroenterology