In vitro model for predicting the access and distribution of drugs in the brain using hCMEC/D3 cells

The hCMEC/D3 cell line as a model of the human blood brain barrier

Babette B. Weksler, Ignacio A. Romero, Pierre‐Olivier Couraud · Fluids and Barriers of the CNS · 2013 · 771 citations · Full text

Medicine, Neuroscience, Pharmacology +16

Structure−Brain Exposure Relationships in Rat and Human Using a Novel Data Set of Unbound Drug Concentrations in Brain Interstitial and Cerebrospinal Fluids

Markus Fridén, Susanne Winiwarter, Gunilla Jerndal et al. · Journal of Medicinal Chemistry · 2009 · 225 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

In Vitro Methods for Estimating Unbound Drug Concentrations in the Brain Interstitial and Intracellular Fluids

Markus Fridén, Anubha Gupta, Madeleine Antonsson et al. · Drug Metabolism and Disposition · 2007 · 201 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Comparison of a Rat Primary Cell-Based Blood-Brain Barrier Model With Epithelial and Brain Endothelial Cell Lines: Gene Expression and Drug Transport

Szilvia Veszelka, András Tóth, Fruzsina R. Walter et al. · Frontiers in Molecular Neuroscience · 2018 · 139 citations · Full text

Medicine, Neuroscience, Pharmacology +15

Quantitative Evaluation of the Impact of Active Efflux by P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier on the Predictability of the Unbound Concentrations of Drugs in the Brain Using Cerebrospinal Fluid Concentration as a Surrogate

Hiroshi Kodaira, Hiroyuki Kusuhara, Takuya Fujita et al. · Journal of Pharmacology and Experimental Therapeutics · 2011 · 130 citations

Pharmacy, Pharmacokinetics, Pharmacology +17