Combination of cassette-dosing and microsampling for reduced animal usage for antibody pharmacokinetics in cynomolgus monkeys, wild-type mice, and human FcRn transgenic mice

Differences in promiscuity for antibody–FcRn interactions across species: implications for therapeutic antibodies

Raimund J. Ober, Caius G. Radu, Victor Gheţie et al. · International Immunology · 2001 · 494 citations

Pharmacy, Immunology, Molecular Biology +17

Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization

Tomoyuki Igawa, Shinya Ishii, Tatsuhiko Tachibana et al. · Nature Biotechnology · 2010 · 351 citations

Pharmacy, Biotechnology, Immunology +13

Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease

Stefka B. Petkova, Shreeram Akilesh, Thomas J. Sproule et al. · International Immunology · 2006 · 309 citations

Life Sciences, Immunology, Pathology +13

Formation, Distribution, and Elimination of Infliximab and Anti-Infliximab Immune Complexes in Cynomolgus Monkeys

Jeannie R. Rojas, Ronald P. Taylor, Mark R. Cunningham et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 128 citations

Life Sciences, Immunology, Pharmacology +17

Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies

Lindsay B. Avery, Mengmeng Wang, Mania Kavosi et al. · mAbs · 2016 · 114 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17