Concepedia

A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models

Weijin Wang, Qiuzhi Zhou, Tao Jiang, Shihong Li, Jinwang Ye, Jie Zheng, Xin Wang, Yanchao Liu, Minmin Deng, Dan Ke,

Theranostics · 2021 · 220 citations · 23 references

DOIFull text

Open access

Concepts

Abstract

, which provides a promising drug candidate for AD and the related tauopathies.

References

23

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

Maj-Linda B. Selenica, Milene L. Brownlow, Jeffy P. Jimenez et al. · Neurodegenerative Diseases · 2012 · 10.4K citations · Full text

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The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

Dominique Toullec, P. Pianetti, Hervé Coste et al. · Journal of Biological Chemistry · 1991 · 2.5K citations · Full text

, , +11

Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

Erik D. Roberson, Kimberly Scearce‐Levie, Jorge J. Palop et al. · Science · 2007 · 1.9K citations

, , +17

Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

Erik D. Roberson, Brian Halabisky, Jong W. Yoo et al. · Journal of Neuroscience · 2011 · 652 citations · Full text

, , +17

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

Cristian A. Lasagna‐Reeves, Diana L. Castillo‐Carranza, Urmi Sengupta et al. · Molecular Neurodegeneration · 2011 · 618 citations · Full text

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