American Journal of Physiology-Gastrointestinal and Liver Physiology · 2021 · 72 citations · 17 references
Life SciencesCell BiologyMolecular BiologyInflammationMitochondrial BiologyMitochondrial GeneticsInflammasome ActivationMitochondrial DysfunctionMitochondrial PhysiologyMitochondrial SignalingMitochondrial Stress ResponsesMitochondrial TranscriptionAim2 InflammasomeMitochondrial Dna GeneticsMitochondrial Dna Lagging Strand SynthesisMitochondrial Dna Leading Strand SynthesisMitochondrial Dna-triggered Inflammasome ActivationMitochondrial Stress Signaling PathwaysMitochondrial TargetsPyroptosis Mechanisms
Mitochondria damage exacerbates NAFLD through trigerring AIM2 inflammasome activation and hepatocyte pyroptosis. This study provides novel insights into the underlying mechanisms of mitochondrial DNA synthesis in NAFLD and also suggests potential therapeutic targets for the treatment of NAFLD.
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