Concepedia

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

Zhenyu Zhong, Shuang Liang, Elsa Sánchez‐López, Feng He, Shabnam Shalapour, Xue-Jia Lin, Jerry Wong, Siyuan Ding, Ekihiro Seki, Bernd Schnabl,

Nature · 2018 · 1.2K citations · 18 references

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References

18

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou, Amir S. Yazdi, Philippe Menu et al. · Nature · 2010 · 5.4K citations

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Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

Masahiro Yamamoto, Shintaro Sato, Hiroaki Hemmi et al. · Science · 2003 · 3.2K citations

, , +17

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Veit Hornung, Franz Bauernfeind, Annett Halle et al. · Nature Immunology · 2008 · 3K citations · Full text

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Kiichi Nakahira, Jeffrey A. Haspel, Vijay Rathinam et al. · Nature Immunology · 2010 · 3K citations · Full text

, , +15

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

Kenichi Shimada, Timothy R. Crother, Justin N. Karlin et al. · Immunity · 2012 · 2.2K citations · Full text

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