Mechanistic elucidation of the oral pungency of capsaicin-related dietary components: Spatial structural insights

Beware of q2!

Alexander Golbraikh, Alexander Tropsha · Journal of Molecular Graphics and Modelling · 2002 · 3.7K citations

Further exploring r metrics for validation of QSPR models

Probir Kumar Ojha, Indrani Mitra, Rudra Narayan Das et al. · Chemometrics and Intelligent Laboratory Systems · 2011 · 554 citations

Pharmacy, Biostatistics, Method Validation +11

Targeting the Intracellular Environment in Cystic Fibrosis: Restoring Autophagy as a Novel Strategy to Circumvent the CFTR Defect

Valeria Rachela Villella, Speranza Esposito, Emanuela M. Bruscia et al. · Frontiers in Pharmacology · 2013 · 388 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel

Fan Yang, Xian Xiao, Wei Cheng et al. · Nature Chemical Biology · 2015 · 308 citations · Full text

Natural Sciences, Biophysics, Molecular Biology +15

Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels

Diana M. Bautista, Yaron M. Sigal, Aaron D. Milstein et al. · Nature Neuroscience · 2008 · 254 citations

Life Sciences, Neuroscience, Pharmacology +12