Concepedia

Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy

Minke A.E. Rab, Jennifer Bos, Brigitte A. van Oirschot, Stephanie van Straaten, Penelope A. Kosinski, Victor Chubukov, Hyeryun Kim, Heidi Mangus, Roger E. G. Schutgens, Gerard Pasterkamp,

Blood · 2021 · 45 citations · 15 references

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References

15

Red Cell Metabolism: A Manual of Biochemical Methods.

Annals of Internal Medicine · 1971 · 2.3K citations

, , +11

Red Cell Metabolism. A Manual of Biochemical Methods.

Annals of Internal Medicine · 1975 · 1.8K citations

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Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Dimitrios Anastasiou, George Poulogiannis, John M. Asara et al. · Science · 2011 · 1.2K citations · Full text

, , +17

Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency

Rachael F. Grace, Christian Rosé, D. Mark Layton et al. · New England Journal of Medicine · 2019 · 159 citations · Full text

, , +13

AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency

Charles Kung, Jeff Hixon, Penelope A. Kosinski et al. · Blood · 2017 · 129 citations · Full text

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