Formulation, characterization and antimicrobial studies of lyophilized luliconazole nanosuspension for enhancing solubility using modified polymer

Abstract

Formulation and characterization of Luliconazole (LZL) nanosuspensions using modified starch ester polymer to increase solubility. X-ray analysis of A6 and B4 lyophilized nanosuspensions confirmed amorphous nature having % relative crytalinilty of 48.453, 41.374% and crystallite size of 21 and 35 nm; respectively. However, solubility of lyophilized nanosuspension improved by more than 370 fold in comparison to that of pure LZL-API which brings it in soluble form at pH-1.2. In-vitro antifungal studies revealed that lyophilized nanosuspension enhanced activity against fungi yeasts (Candida albican, Candida auris) and Aspergillus (A. Flavus, A. Nigar) when compared to LZL marketed cream.