Excessive <i>O</i> -GlcNAcylation Causes Heart Failure and Sudden Death

Abstract

Our data provide evidence that excessive <i>O</i>-GlcNAcylation causes cardiomyopathy, at least in part, attributable to defective energetics. Enhanced OGA activity is well tolerated and attenuation of <i>O</i>-GlcNAcylation is beneficial against pressure overload-induced pathologic remodeling and heart failure. These findings suggest that attenuation of excessive <i>O</i>-GlcNAcylation may represent a novel therapeutic approach for cardiomyopathy.