Science Advances · 2021 · 100 citations · 45 references
Life SciencesNeurologyNeuroscienceMolecular NeurobiologyMolecular NeuroscienceNeurodegenerationAmyotrophic Lateral SclerosisMolecular Basis Of NeurodegenerationMotor Neuron DiseasesNeurodegeneration MechanismsNeurodegenerative DiseasesNeurodegenerative DisordersAmyotrophic Lateral Sclerosis AutophagyAmyotrophic Lateral Sclerosis Lysosomal DysfunctionAmyotrophic Lateral Sclerosis PathologyMotor Neuron Disease ModelsNeurodegeneration GeneticsNeurodegenerative GeneticsSod1 PathologySporadic Amyotrophic Lateral Sclerosis
) within the significant pathways as relevant to ALS. We conclude that the disparate genetic etiologies of this fatal neurological disease converge on a smaller number of final common pathways and cell types.
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Comprehensive Integration of Single-Cell Data
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The Molecular Signatures Database Hallmark Gene Set Collection
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