Concepedia

Sod1 Pathology

Sod1 Pathology is a molecular pathogenic mechanism, within the context of amyotrophic lateral sclerosis research, characterized by the aggregation and dysfunction of mutant superoxide dismutase 1 (SOD1) protein leading to selective motor neuron degeneration.

1.8K

Publications

148.8K

Citations

8.4K

Authors

1.9K

Institutions

Publications per year

2017–2026

417

Parents

Publications

1.8K

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

Philip C. Wong, Carlos A. Pardo, David Borchelt et al. · Neuron · 1995 · 1.4K citations

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ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

Lucie Bruijn, Mark W. Bêcher, Michael K. Lee et al. · Neuron · 1997 · 1.3K citations · Full text

, , +17

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

Lucie Bruijn, Megan K. Houseweart, Shinsuke Kato et al. · Science · 1998 · 1.2K citations

, , +17

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

Makiko Nagai, Diane B. Ré, Tetsuya Nagata et al. · Nature Neuroscience · 2007 · 1.2K citations

, , +12

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

Albrecht M. Clement, Minh Dang Nguyen, Elizabeth A. Roberts et al. · Science · 2003 · 1.1K citations

, , +17

1–5 of 1.8K

Authors

8.4K

  1. DW
    Don W. Cleveland

    Ludwig Cancer Research, United States

    45 publications · 13.8K citations

    44

    h-index

  2. PM
    Peter M. Andersen

    Umeå University, Sweden

    52 publications · 5K citations

    33

    h-index

  3. RH
    Robert H. Brown

    Massachusetts General Hospital, United States

    35 publications · 6.9K citations

    31

    h-index

  4. SL
    Stefan L. Marklund

    Umeå University, Sweden

    36 publications · 3.2K citations

    28

    h-index

  5. DB
    David Borchelt

    University of Florida, United States

    38 publications · 7.3K citations

    27

    h-index

1–5 of 8.4K

Institutions

1.9K

  1. Johns Hopkins University

    Baltimore, United States

    47 h-index

    262 publications

    72.2K citations

  2. University of California San Diego

    San Diego, United States

    39 h-index

    149 publications

    38.9K citations

  3. University of Massachusetts Chan Medical School

    Worcester, United States

    39 h-index

    141 publications

    14.4K citations

  4. Massachusetts General Hospital

    Boston, United States

    37 h-index

    200 publications

    30.2K citations

  5. Ludwig Cancer Research

    New York, United States

    36 h-index

    156 publications

    55.6K citations

  6. Umeå University

    Umeå, Sweden

    36 h-index

    204 publications

    16.7K citations

  7. Harvard University

    Cambridge, United States

    34 h-index

    142 publications

    32.7K citations

  8. Northwestern University

    Evanston, United States

    34 h-index

    165 publications

    20.9K citations

1–8 of 1.9K

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 82 publications · 17.3K citations

    71

    h-index

  2. Journal of Biological Chemistry

    JBC · 78 publications · 10.6K citations

    56

    h-index

  3. Journal of Neurochemistry

    JNC · 77 publications · 8.1K citations

    48

    h-index

  4. Journal of Neuroscience

    46 publications · 7.9K citations

    41

    h-index

  5. Neurobiology of Disease

    58 publications · 4.9K citations

    38

    h-index

1–5