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Publication | Open Access

LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors

DOIFull Paper Access

84

Citations

43

References

2020

Year

Kelli‐Ann Monaco, Scott Delach, Jing Yuan, Yuji Mishina, Paul Fordjour, Emma Labrot, Daniel J. McKay, Ribo Guo, Stacy Higgins, Hui Qin Wang,
Clinical Cancer Research

Abstract

LXH254 is a novel RAF inhibitor, which is able to inhibit dimerized BRAF and CRAF, as well as monomeric BRAF, while largely sparing ARAF.

References

YearCitations

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