Reactive or transgenic increase in microglial TYROBP reveals a TREM2‐independent TYROBP–APOE link in wild‐type and Alzheimer's‐related mice - Concepedia

Concepedia

Publication | Open Access

Reactive or transgenic increase in microglial TYROBP reveals a TREM2‐independent TYROBP–APOE link in wild‐type and Alzheimer's‐related mice

DOI Full Paper Access

59

Citations

49

References

2020

Year

Mickaël Audrain, Jean‐Vianney Haure‐Mirande, Justyna Mleczko, Minghui Wang, Jennifer K. Griffin, Peter St George‐Hyslop, Paul E. Fraser, Bin Zhang, Sam Gandy, Michelle E. Ehrlich

Alzheimer s & Dementia

Abstract

Our results provide evidence that TYROBP-APOE signaling does not require TREM2 and could be an initiating step in establishment of the disease-associated microglia (DAM) phenotype.

References

	Year	Citations

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