Concepedia

Publication | Open Access

Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome

DOIFull Paper Access

79

Citations

32

References

2020

Year

Wenbiao Wang, Dingwen Hu, Yuqian Feng, Caifeng Wu, Yunting Song, Weiyong Liu, Aixin Li, Yingchong Wang, Keli Chen, Mingfu Tian,
BMC Biology

Abstract

We have identified paxillin as a mediator of NLRP3 inflammasome activation. Paxillin plays key roles in ATP-induced activation of the P2X7 receptor and NLRP3 inflammasome by facilitating the formation of the P2X7R-Paxillin-NLRP3 complex.

References

YearCitations

Page 1