Concepedia

Biological implications of PTEN upregulation and altered sodium/iodide symporter intracellular distribution in resveratrol-suppressed anaplastic thyroid cancer cells

Le Xiong, Jun‐Hua Nie, Xiao-Min Lin, Jianbin Wu, Zhen Chen, Bo Xu, Jia Liu

Journal of Cancer · 2020 · 18 citations · 37 references

DOIFull text

Open access

Concepts

Abstract

Objective: Anaplastic thyroid cancer/ATC is a highly aggressive malignancy with extremely poor prognosis. Resveratrol/Res promotes re-differentiation of cancer cells and exerts inhibitory effects on ATC cells. Sodium/iodide symporter/NIS and phosphate and tension homology deleted on chromsome ten/PTEN levels are positively correlated with the grade of thyroid cancer differentiation, while the impact of Res on them remain unknown.

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37

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